SDF-1/CXCR4 Axis on Endothelial Progenitor Cells Regulates Bone Fracture Healing
نویسندگان
چکیده
Yohei Kawakami, M.D., Ph.D., Masaaki Ii, Tomoyuki Matsumoto, M.D., Ph.D., Astuhiko Kawamoto, M.D., Ph.D., Yutaka Mifune, M.D., Ph.D., Tomoya Kuroda, M.D., Ph.D., Tomoaki Fukui, M.D., Ph.D., Takayuki Asahara, M.D., Ph.D., Ryosuke Kuroda, M.D., Ph.D., Masahiro Kurosaka, M.D., Ph.D.. Kobe University Graduate School of Medicine, Kobe, Japan, Institute of Biomedical Research and Innovation, Kobe, Japan, Osaka Medical College, Takatsuki, Japan.
منابع مشابه
SDF-1 Promotes Endochondral Bone Repair during Fracture Healing at the Traumatic Brain Injury Condition
PURPOSES The objective of this study was to investigate the role of stromal cell-derived factor-1 (SDF-1) and its receptor, CXCR4, on bone healing and whether SDF-1 contributes to accelerating bone repair in traumatic brain injury (TBI)/fracture model. MATERIALS AND METHODS Real-time polymerase chain reaction and immunohistochemical analysis were used to detect the expression of SDF-1 during ...
متن کاملStrategies to Stimulate Mobilization and Homing of Endogenous Stem and Progenitor Cells for Bone Tissue Repair
The gold standard for the treatment of critical-size bone defects is autologous or allogenic bone graft. This has several limitations including donor site morbidity and the restricted supply of graft material. Cell-based tissue engineering strategies represent an alternative approach. Mesenchymal stem cells (MSCs) have been considered as a source of osteoprogenitor cells. More recently, focus h...
متن کاملCXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion.
We hypothesized that the CXC chemokine receptor-4 (CXCR4)-stromal-derived factor-1 (SDF-1) axis may be involved in metastasis of CXCR4(+) tumor cells into the bone marrow and lymph nodes, which secrete the alpha-chemokine SDF-1. To explore this hypothesis, we phenotyped by fluorescence-activated cell sorter analysis various human tumor cell lines for expression of CXCR4 and found that it was hi...
متن کاملThe role of SDF-1/CXCR4 in the vasculogenesis and remodeling of cerebral arteriovenous malformation
BACKGROUND Cerebral arteriovenous malformation (AVM) involves the vasculogenesis of cerebral blood vessels and can cause severe intracranial hemorrhage. Stromal cell-derived factor-1 (SDF-1) and its receptor, CXCR4, are believed to exert multiple physiological functions including angiogenesis. Thus, we investigated the role of SDF-1/CXCR4 in the vasculogenesis of cerebral AVM. METHODS Brain A...
متن کاملLow Intensity Pulsed Ultrasound Enhanced Mesenchymal Stem Cell Recruitment through Stromal Derived Factor-1 Signaling in Fracture Healing
Low intensity pulsed ultrasound (LIPUS) has been proven effective in promoting fracture healing but the underlying mechanisms are not fully depicted. We examined the effect of LIPUS on the recruitment of mesenchymal stem cells (MSCs) and the pivotal role of stromal cell-derived factor-1/C-X-C chemokine receptor type 4 (SDF-1/CXCR4) pathway in response to LIPUS stimulation, which are essential f...
متن کامل